Setpoint Nightly — non-hormonal menopause support

The shape of the problem

Most of it lands between 2 and 4 a.m.

Core temperature drops naturally in the early morning hours. With a narrowed zone, that ordinary dip is enough to trip the response — which is why the symptom people describe as "hot flashes" is so often, in practice, a sleep problem.

~80%

of women experience vasomotor symptoms — hot flashes and night sweats — during the menopause transition.

Baker FC et al. Sleep and sleep disorders in the menopausal transition. Sleep Med Clin. 2018.
PMC6092036 →

7.4 yrs

median total duration of frequent vasomotor symptoms — not the six months to two years clinical guidelines long suggested.

Avis NE et al. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015;175(4):531–539.
PMID 25686030 →

39–47%

of perimenopausal women report sleep problems, up from 16–42% before the transition — the complaint that most often sends people looking for help.

Kravitz HM et al. Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women. Sleep. 2008;31(7):979–990.
PMC2491500 →

Four ingredients · Clinical doses · Nothing else

Every ingredient is here at the dose it was studied at.

No hidden doses, no fairy dusting, no filler botanicals added to make the label look busy. Every ingredient is printed on the label at its full amount. If we couldn't hit the studied dose, it isn't in the capsule.

514 mg

EstroG-100® botanical root blend

A standardized blend of three root extracts studied in five published human trials in menopausal women, including randomized placebo-controlled studies.⁴ Selected for what it doesn't do: it doesn't supply hormones and isn't a phytoestrogen.

Vasomotor
comfort

200 mg

Magnesium glycinate

Elemental magnesium in the glycinate form, chosen for absorption and for being gentle on the stomach overnight.

Sleep ·
muscle function

28 mg

Saffron extract (affron®)

A standardized saffron stigma extract studied for mood in midlife women, at the dose used in that research.

Mood
support

2000 IU + 90 mcg

Vitamin D3 with K2 (MK-7)

Bone loss accelerates sharply after the final period. This pair is the least glamorous thing in the bottle and arguably the most important over ten years.

Bone
density

Before you buy

Four things Setpoint won't do.

You have almost certainly been oversold to before, probably by a doctor who had eleven minutes. Here is the version we'd want if we were the one reading.

It is not hormone therapy.

For moderate to severe symptoms, hormone therapy remains the most effective option available, and for many women it is a reasonable one. If that's on the table for you, talk to a menopause-trained clinician first. Setpoint is for people who can't take it, don't want it, or want something alongside it.

It won't work for everyone.

In the research behind our lead ingredient, the effect is real and meaningful on average — and average means some people feel a lot and some feel little. Anyone promising you a universal result is selling, not informing.

It is not fast.

Give it eight to twelve weeks before you judge it. If a supplement claims to change your nights inside a week, that claim is doing marketing work, not biological work.

There's no black cohosh in it.

It's the most common ingredient in this category and we left it out on purpose. Case reports of liver injury are rare but they exist, and we weren't willing to put a rare serious risk into something you take every night for years.

Who's behind this

A mother and her son.

Setpoint is run by the two of us — and one of us is the reason it exists. She spent years in the 3 AM wake-ups, and because of her medical history, hormone therapy was never an option her doctors would put on the table. The plan she was handed instead: layers, a fan, patience.

So we're building what we couldn't find on the shelf — every ingredient at its studied dose, printed on the label, nothing hidden, and nothing sold until manufacturing and third-party testing are done. She weighs every decision as the person who'll take it every night. He reads the studies. What you get is the version we'd want our own family taking, because that's exactly what it is.

Setpoint Nightly · Not yet available for purchase

We're not selling yet — but you can be first to know.

$49 / month · subscribe, cancel anytime Best value

or $59 one-time purchase · planned launch pricing

Manufacturing and lab testing are still in progress. Join the list and we'll email you the moment it's real — no charge, no commitment.

You'll be notified before anyone else can buy.
Third-party tested for identity, potency, heavy metals and microbes — before launch, not after.
No spam. Unsubscribe from any email.
Manufactured in a cGMP-registered facility.

Questions

The ones that actually get asked.

Can I take this with hormone therapy?

Many people do, but this is a question for your prescriber, not for us. Bring them the label — every ingredient and dose is printed on it, nothing hidden.

Why at night?

Two reasons. The magnesium is better suited to the evening, and the symptoms most people want help with cluster in the early morning hours. One dose, one time, harder to forget.

I'm perimenopausal, not menopausal. Is this for me?

The transition years are when most people first notice the change and when they're most often told to wait it out. Nothing in the formula is keyed to a specific stage.

What if it does nothing for me?

Once we're actually selling: email us inside 60 nights and we refund the order, no need to send the bottle back. That policy isn't live yet — right now, joining the waitlist doesn't charge you anything at all.

Who shouldn't take it?

If you are pregnant or breastfeeding, have a hormone-sensitive condition, have liver or kidney disease, or take prescription medication, check with your clinician before starting. This applies to any supplement, and anyone who tells you otherwise is not worth buying from.

References

Baker FC, de Zambotti M, Colrain IM, Bei B. Sleep and sleep disorders in the menopausal transition. Sleep Med Clin. 2018;13(3):443–456. PMC6092036
Avis NE, Crawford SL, Greendale G, et al. Duration of menopausal vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015;175(4):531–539. PMID 25686030
Kravitz HM, Zhao X, Bromberger JT, et al. Sleep disturbance during the menopausal transition in a multi-ethnic community sample of women. Sleep. 2008;31(7):979–990. PMC2491500
Chang A, Kwak BY, Yi KT, Kim JS. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. 2012;26(4):510–516. doi:10.1002/ptr.3597